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fluoxetine
Fluoxetine, a selective serotonin reuptake inhibitor (SSRI), represents one of the most widely prescribed antidepressants globally. Marketed under brand names like Prozac, this compound has fundamentally altered psychiatric treatment paradigms since its introduction in the late 1980s. Unlike earlier tricyclic antidepressants, fluoxetine offered a more favorable side effect profile while maintaining robust efficacy for major depressive disorder. Its mechanism—selectively blocking serotonin reuptake in synaptic clefts—creates a gradual neuromodulatory effect that distinguishes it from immediate-acting psychotropics.
abilify
Aripiprazole, marketed under the brand name Abilify, represents a significant advancement in psychopharmacology as a second-generation antipsychotic medication. Unlike first-generation antipsychotics that primarily act through dopamine D2 receptor antagonism, aripiprazole functions as a partial dopamine agonist - a unique mechanism that provides both stabilizing and modulating effects on dopaminergic neurotransmission. This pharmacological profile has established its role across multiple psychiatric conditions including schizophrenia, bipolar disorder, major depressive disorder (as adjunctive therapy), and irritability associated with autistic disorder.
amitriptyline
Amitriptyline is a tricyclic antidepressant (TCA) that has been a workhorse in clinical practice for over half a century. While officially classified as an antidepressant, its utility extends far beyond mood disorders into chronic pain management, migraine prophylaxis, and various off-label uses. Its complex pharmacology, targeting multiple neurotransmitter systems, makes it both highly effective and challenging to manage. I remember my first complex case with this medication involved a 62-year-old female with post-herpetic neuralgia who’d failed gabapentin and pregabalin.
Anafranil: Potent Serotonin Reuptake Inhibition for Obsessive-Compulsive Disorder - Evidence-Based Review
Anafranil, known generically as clomipramine hydrochloride, is a tricyclic antidepressant (TCA) belonging to the dibenzazepine class. It’s primarily indicated for the treatment of obsessive-compulsive disorder (OCD), acting as a potent serotonin reuptake inhibitor. Beyond its psychiatric applications, it’s also used off-label for various anxiety disorders, chronic pain syndromes, and certain sleep disorders. Its significance in modern medicine lies in its robust efficacy for treatment-resistant OCD, often serving as a benchmark against which newer agents are measured.
bystolic
Bystolic represents one of those interesting cases where we got a beta-blocker that actually behaves quite differently from the classic propranolol model. When I first started prescribing it back in 2008, most of us were still thinking of beta-blockers as primarily for arrhythmias with some blood pressure benefits, but nebivolol really forced us to reconsider the entire class. Bystolic: Advanced Beta-Blocker Therapy for Hypertension and Cardiovascular Protection 1. Introduction: What is Bystolic?
celexa
Celexa, known generically as citalopram, is a selective serotonin reuptake inhibitor (SSRI) antidepressant medication, not a dietary supplement or medical device. It’s FDA-approved for treating major depressive disorder in adults and is sometimes used off-label for other conditions. This monograph will detail its clinical profile, mechanism, and real-world application based on extensive prescribing experience. ## 1. Introduction: What is Celexa? Its Role in Modern Medicine Celexa (citalopram hydrobromide) is a widely prescribed antidepressant belonging to the SSRI class.
clomid
Clomiphene citrate, commonly known by its brand name Clomid, represents one of the foundational oral medications in reproductive medicine. As a selective estrogen receptor modulator (SERM), it occupies a unique therapeutic niche for ovulation induction in anovulatory women, particularly those with polycystic ovary syndrome (PCOS). Its mechanism—essentially tricking the pituitary into perceiving low estrogen levels—triggers increased gonadotropin-releasing hormone (GnRH) pulsatility, leading to elevated follicle-stimulating hormone (FSH) and luteinizing hormone (LH) secretion.
cymbalta
Duloxetine hydrochloride, marketed under the brand name Cymbalta, represents a significant advancement in psychopharmacology as a serotonin-norepinephrine reuptake inhibitor (SNRI). Unlike earlier antidepressants that primarily targeted serotonin alone, this dual mechanism provides broader neuromodulatory effects that have proven particularly valuable for conditions where both pain pathways and mood regulation are disrupted. We initially viewed it as just another SSRI alternative back in 2004 when it first got FDA approval, but the clinical reality turned out to be much more nuanced.
desyrel
TraZODone hydrochloride, commonly known by its brand name Desyrel, is an antidepressant medication belonging to the class of serotonin antagonist and reuptake inhibitors (SARIs). Initially developed in the 1970s and approved by the FDA in 1982, it occupies a unique niche in psychopharmacology due to its multifaceted mechanism. While primarily indicated for major depressive disorder, its strong sedative properties have made it a versatile agent in managing insomnia, particularly in patients where traditional sleep aids are contraindicated.